What is Buy etizolam-pill online?
Buy etizolam-pill online is a thienodiazepine, which is a benzodiazepine analog. In other words, chemically, it is slightly different than a benzodiazepine like Xanax. Although not available in the U.S., it is deemed a Schedule drug in some states because it can be found online and on the street as a recreational drug. Etizolam has sedative effects and is a muscle relaxant. It interacts with a neurotransmitter in the central nervous system that controls the firing of neurons. As a result, it is a depressant drug that slows everything down.Long-term use can lead to blepharospasm or twitching of the eyelids. It may also cause a specific kind of skin lesion, although that is a rare side effect of the drug.Etizolam is selectively a full agonist at GABA-A receptors to increase GABAergic transmission and enhance GABA-induced Cl- currents 1. It is reported to bind to the benzodiazepine binding site which is located across the interface between the alpha and gamma subunits. Benzodiazapines are reported to only bind to receptors that contain gamma 2 and alpha 1/2/3/5 subunits 7. Alpha-1-containing receptors mediate the sedative effects of etizolam whereas alpha-2 and alpha-3 subunit-containing receptors mediate the anxiolytic effect . Etizolam shows high potency and affinity towards GABA-A receptor with alpha 1 beta 2 gamma 2S subunit combination . By binding to the regulatory site of the receptor, etizolam potentiates GABA transmission by facilitating the opening of GABA-induced chloride channels . Etizolam is a specific antagonist at PAFR. It inhibits PAF-induced platelet aggregation by inhibiting PAF binding to the receptors located on the surface of platelets with an IC50 of 22nM 5. Metabolism:Biotransformation of etizolam is extensive and involves hydroxylation and conjugation . The main metabolite formed via 1′-hydroxylation is α-hydroxyetizolam which retains pharmacological activity comparable to that of the parent drug, indicating that the action of metabolites may contribute to the clinical effects of etizolam . CYP3A4 is predicted to be the main CYP enzyme responsible for mediating etizolam metabolism. CYP2C18 and CYP2C19 are also involved in the metabolic pathways.